Important Safety Information
Contraindications
Apidra is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Apidra or any of its excipients.
Warnings and Precautions
Insulin pens and needles must never be shared between patients, even if the needle is changed. Do NOT reuse needles.
Monitor blood glucose in all patients treated with insulin. Modify insulin regimens only under medical supervision. Changes in insulin regimen including, strength, manufacturer, type, injection site or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant oral antidiabetic treatment. Dosing should be individualized based on patient characteristics and lifestyle.
Repeated insulin injections into areas of lipodystrophy or localized cutaneous amyloidosis may result in hyperglycemia; sudden change in the injection site (to unaffected area) has been reported to result in hypoglycemia. Advise patients to rotate injection site to unaffected areas and closely monitor for hypoglycemia.
Hypoglycemia is the most common adverse reaction associated with insulins, including Apidra, and maybe life-threatening.
To avoid medication errors between APIDRA and other insulins, instruct patients to always check the insulin label before each injection.
All insulin products, including Apidra, can cause hypokalemia. Untreated hypokalemia may cause respiratory paralysis, ventricular arrhythmia, and death. Use caution in patients who may be at risk for hypokalemia.
Severe life-threatening, generalized allergy, including anaphylaxis, can occur with insulin products, including APIDRA. If hypersensitivity reactions occur, discontinue APIDRA, treat per standard of care and monitor until symptoms and signs resolve.
Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs) with insulin. Observe for signs and symptoms of heart failure. Consider dosage reduction or discontinuation of TZD if heart failure occurs.
Malfunction of the insulin pump or insulin infusion set or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis. Patients using insulin infusion pump therapy must be trained to administer insulin by injection and have alternate insulin therapy available in case of pump failure.
Adverse Reactions
Adverse reactions commonly associated with Apidra include hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, pruritus, rash, and weight gain.
Drug Interactions
Certain drugs may affect glucose metabolism, requiring insulin dose adjustment and close monitoring of blood glucose. The signs of hypoglycemia may be reduced in patients taking anti-adrenergic drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine).
Important Safety Information for Apidra® (insulin glulisine injection) SoloSTAR®
Apidra SoloSTAR is a disposable single-patient-use prefilled insulin pen. To help ensure an accurate dose each time, patients should follow the steps in the Instruction Leaflet accompanying the pen; otherwise they may not get the correct amount of insulin, which may affect their blood glucose.
Important Safety Information for Apidra Use in Pump
Inform patients to replace the infusion sets (reservoir, tubing, and catheter) and the Apidra in the reservoir at least every 48 hours and select a new infusion site. Pump failure or insulin infusion set or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis. Prompt identification and correction of the cause is necessary. Interim subcutaneous injections with APIDRA may be required. Patients using a pump must be trained to administer insulin by injection and have alternative insulin therapy available in case of pump system failure.
Click here for Full Prescribing Information for Apidra.
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Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.
*Eligibility Restrictions & Offer Terms:
Insulins Valyou Savings Program:
Sanofi insulins included in this program are: ADMELOG® (insulin lispro injection) 100 Units/mL, TOUJEO® SoloStar® (insulin glargine injection) 300 Units/mL, TOUJEO® Max SoloStar® (insulin glargine injection) 300 Units/mL, LANTUS® (insulin glargine injection) 100 Units/mL, INSULIN GLARGINE injection 100 Units/mL (U-100) and APIDRA® (insulin glulisine injection) 100 Units/mL.
This offer is not valid for prescriptions covered by or submitted for reimbursement under Medicare, Medicaid, VA, DOD, TRICARE, similar federal or state programs, including any state pharmaceutical programs, or commercial/private insurance. Only people without prescription medication insurance can apply for this offer. Void where prohibited by law. For the duration of the program, eligible patients will pay $35 per 30 Day Supply. To pay $35 per 30 Day Supply, you must fill all your Sanofi Insulin prescriptions at the same time, together each month. Not valid for SOLIQUA 100/33 (insulin glargine and lixisenatide) injection 100 Units/mL and 33 mcg/mL. When using the Insulins Valyou Savings Card, prices are guaranteed for 12 consecutive monthly fills. The Insulins Valyou Savings Program applies to the cost of medication. There are other relevant costs associated with overall treatment. Sanofi reserves the right to rescind, revoke, terminate, or amend this offer, eligibility, and terms of use at any time without notice. Upon registration, patients will receive all program details.
Sanofi Copay Program:
This offer is not valid for prescriptions covered by or submitted for reimbursement under Medicare, Medicaid, VA, DOD, TRICARE, or similar federal or state programs including any state pharmaceutical assistance program. If you have an Affordable Care (Health Care Exchange) plan, you may still be qualified to receive and use this savings card. Please note: The Federal Employees Health Benefits (FEHB) Program is not a federal or state government healthcare program for purposes of the savings program. Void where prohibited by law.
- Apidra: $0 copay with maximum savings up to $100 per pack up to 1 pack per fill.
Savings may vary depending on patients’ out-of-pocket costs. Upon registration, patients receive all program details. Sanofi US reserves the right to change the maximum cap amount, rescind, revoke or amend these programs without notice.
REFERENCES:
- Sheldon B, Russel-Jones D, Wright J. Diabetes Obes Metab. 2009;11:5-9.
- Becker RHA, Frick AD, Burger F, Potgieter JH, Scholtz H. Exp Clin Endocrinol Diabetes. 2005;13:435-443.
- Bolli GB, Luzio S, Marzotti S, et al. Diabetes Obes Metab. 2011;13:251-257.
- Heise T, Nosek L, Spitzer H, et al. Diabetes Obes Metab. 2007;9:746-753.
- Apidra® Prescribing Information.
- NovoLog® Prescribing Information.
- Humalog® Prescribing Information.
All registered trademarks cited are the property of their respective owners.
REFERENCES:
†Humalog® savings card information. Available at: https://www.humalog.com/hcp/humalog-u200/#savings-card-section.
NovoLog® savings card information. Available at: https://www.novologpro.com/savings-and-coverage.html.
‡Relay: Data Months: September 2016 – August 2017.
All registered trademarks cited are the property of their respective owners.
REFERENCES:
- AACE/ACE Consensus Statement. Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm – 2016 Executive Summary. T2D Algorithm, Executive Summary. Endocr Pract. 2016;22(No.1).
- Apidra® Prescribing Information.
- NovoLog® Prescribing Information.
- Humalog® Prescribing Information.
All registered trademarks cited are the property of their respective owners.
Indication and Usage for Lantus® (insulin glargine injection) 100 Units/mL
Lantus is a long-acting insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus. Lantus should be administered once a day at the same time every day.
Limitations of Use: Lantus is not recommended for the treatment of diabetic ketoacidosis.
Important Safety Information
Contraindications
Lantus is contraindicated during episodes of hypoglycemia and in patients hypersensitive to insulin glargine or one of its excipients.
Warnings and Precautions
Insulin pens, needles, or syringes must never be shared between patients. Do NOT reuse needles.
Monitor blood glucose in all patients treated with insulin. Modify insulin regimen only under medical supervision. Changes in insulin regimen including, strength, manufacturer, type, injection site or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant oral antidiabetic treatment.
Repeated insulin injections into areas of lipodystrophy or localized cutaneous amyloidosis may result in hyperglycemia; sudden change in the injection site (to unaffected area) has been reported to result in hypoglycemia. Advise patients to rotate injection site to unaffected areas and closely monitor for hypoglycemia.
Do not dilute or mix Lantus with any other insulin or solution. If mixed or diluted, the solution may become cloudy, and the onset of action/time to peak effect may be altered in an unpredictable manner. Do not administer Lantus via an insulin pump or intravenously because severe hypoglycemia can occur.
Hypoglycemia is the most common adverse reaction of insulin therapy, including Lantus, and may be life-threatening.
Medication errors, such as accidental mix-ups between basal insulin products and other insulins, particularly rapid-acting insulins, have been reported. Patients should be instructed to always verify the insulin label before each injection.
Severe life-threatening, generalized allergy, including anaphylaxis, can occur. Discontinue Lantus, treat and monitor until symptoms resolve.
A reduction in the Lantus dose may be required in patients with renal or hepatic impairment.
As with all insulins, Lantus use can lead to life-threatening hypokalemia. Untreated hypokalemia may cause respiratory paralysis, ventricular arrhythmia, and death. Closely monitor potassium levels in patients at risk of hypokalemia and treat if indicated.
Fluid retention, which may lead to or exacerbate heart failure, can occur with concomitant use of thiazolidinediones (TZDs) with insulin. These patients should be observed for signs and symptoms of heart failure. If heart failure occurs, dosage reduction or discontinuation of TZD must be considered.
Drug Interactions
Certain drugs may affect glucose metabolism, requiring insulin dose adjustment and close monitoring of blood glucose. The signs of hypoglycemia may be reduced in patients taking anti-adrenergic drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine).
Adverse Reactions
Adverse reactions commonly associated with Lantus include hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, pruritus, rash, edema and weight gain.
Important Safety Information for Lantus SoloSTAR®
Lantus SoloSTAR is a disposable single-patient-use prefilled insulin pen. To help ensure an accurate dose each time, patients should follow all steps in the Instruction Leaflet accompanying the pen: otherwise they may not get the correct amount of insulin, which may affect their blood glucose.
Click here for Full Prescribing Information for Lantus.
Click here for information on Sharps Medical Waste Disposal.
Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.
FAQs
Apidra® (insulin glulisine injection) 100 Units/mL? ›
Prescription Apidra is a fast (rapid) acting insulin used for adults and children with diabetes mellitus to control high blood sugar. It is not known if APIDRA is safe or effective in children less than 4 years of age with type 1 diabetes or in children with type 2 diabetes.
What is Apidra 100u ml? ›Apidra 100IU/ml Solution for Injection is used to improve blood sugar control in people with type 1 and type 2 diabetes mellitus. It is a fast-acting type of insulin that helps to lower blood sugar levels after meals and reduce the chances of developing serious complications of diabetes.
How many units is a ml of Apidra? ›Apidra Dosage and Basal Bolus Regimen | Apidra® (insulin glulisine injection) 100 Units/mL.
Does Apidra come in 100 and 200 units? ›Each ml contains 100 Units insulin glulisine (equivalent to 3.49 mg). Each vial contains 10 ml of solution for injection, equivalent to 1000 Units.
Is Apidra insulin a glulisine? ›Important Safety Information for Apidra® (insulin glulisine injection) SoloStar® Apidra SoloSTAR is a disposable single-patient-use prefilled insulin pen. Please talk to your healthcare provider about proper injection techniques and follow instructions in the Instruction Leaflet that accompanies the pen.
How many units of Apidra should I take? ›The dosage of APIDRA must be individualized. Blood glucose monitoring is essential in all patients receiving insulin therapy. The total daily insulin requirement may vary and is usually between 0.5 to 1 Unit/kg/day.
Is Apidra same as regular insulin? ›Apidra(R) has a more rapid onset of action and a shorter duration of action than regular human insulin, and offers people with diabetes greater mealtime dosing flexibility versus regular human insulin because they can take Apidra(R) either before or after a meal (within 15 minutes before or within 20 minutes after ...
How many mL is 100 units of insulin? ›The concentration of insulin is the number of units of insulin in one milliliter (mL). Insulin vials and pens commonly have a concentration of 100 units in 1 mL (100 units/mL), which is called U-100.
Is 30 units 1 mL? ›1.0ml syringe
3/10ml syringe draws up to 30 units.
That means there are 100 units of insulin in each milliliter (mL) of insulin. Humalog® insulin comes in 3 mL (300 units) vials or 10 mL (1000 units) vials. All other types of insulin come in 10 mL (1000 units) vials.
What does 100 units of insulin mean? ›
Insulin strength
The standard and most commonly used strength in the United States today is U-100, which means it has 100 units of insulin per milliliter of fluid, though U-500 insulin is available for patients who are extremely insulin resistant.
Humalog® (insulin lispro) is a rapid acting insulin, which is available as 100 units/ml and as a high strength insulin as 200 units/ml. The 100 units/ml and 200 units/ml preparations are bioequivalent which means there is no dose conversion required when switching between different strength products.
How many mg is 100 units of insulin? ›Each ml contains 100 units of insulin lispro* (equivalent to 3.5 mg).
What is equivalent to Apidra? ›Fiasp (insulin aspart injection) and Apidra (insulin glulisine [rdna origin] inj) are rapid-acting human insulin analogs used to improve glycemic control in adults with diabetes mellitus.
Is Apidra insulin long or short? ›Apidra is a short-acting insulin that is used in combination with intermediate- or long-acting insulins or insulin analogues (modified forms of insulin).
How much is insulin glulisine? ›Apidra SoloStar (insulin glulisine) is a member of the insulin drug class and is commonly used for Diabetes - Type 1, Diabetes - Type 2, Diabetic Ketoacidosis, and others. The cost for Apidra SoloStar injectable solution (100 units/mL) is around $587 for a supply of 15 milliliters, depending on the pharmacy you visit.
How much insulin should I take if my blood sugar is 250? ›| Blood glucose | 60–120 | 270–300 |
|---|---|---|
| Insulin correction | 0 units | 4 units |
You might start with four to six units of insulin. Your dose may go up two to three units every 3 days until you reach your blood sugar target. Another way to do this is to match your insulin to the amount of carbs you eat.
How many units of insulin does the average person need? ›Summary. Many people with diabetes need to take insulin shots to stay healthy. The number of units of insulin that you need each day is called your total daily insulin requirement. This is estimated by dividing your body weight by 4.
How long does Apidra insulin work for? ›Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin glulisine is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours.
Does Apidra need to be refrigerated? ›
Storing opened (in use) Apidra: Store the vial in a refrigerator or at cool room temperature and use within 28 days. Store the injection pen at cool room temperature (do not refrigerate) and use within 28 days.
Which is better Apidra or Humalog? ›Summary. Humalog (insulin lispro) is a fast-acting insulin that controls blood sugar around meal times for both type 1 and type 2 diabetes. Apidra (insulin glulisine) is a rapid-acting insulin that controls blood sugar for people with either type 1 diabetes or type 2 diabetes.
Is 100 units insulin too much? ›The strength of insulin may also vary. The most common strength is U-100, or 100 units of insulin per milliliter of fluid. People who are more insulin-resistant may require more than that, so the drug is available at up to U-500 strength.
Is a 100 unit insulin syringe 1 mL? ›Most syringes come in measures of 30-units or 0.3 milliliters (ml), 50 units (0.5 ml), and 100 units (1 ml). These measures refer to the barrel size and how much insulin the syringe can hold. The barrels feature markings at 1- or 2-unit intervals to help people measure their dose.
How long will 100 units of insulin last? ›| Insulin Name | Expiration Upon Opening or Removing from Refrigerator |
|---|---|
| Regular Insulin (Humulin R) 100 units/mL | 31 days |
| Regular Insulin (Humulin R) 500 units/mL | 40 days |
| Insulin Aspart (Novolog) | 28 days |
| Insulin Aspart; Insulin Aspart Protamine (Novolog Mix 70/30) | 28 days |
How is it measured? Insulin is measured in International Units (units); most insulin is U-100, which means that 100 units of insulin are equal to 1 mL.
How many mL is 1 unit? ›One unit is 10ml (millilitres) or 8g (grams) of pure alcohol. Because alcoholic drinks come in different strengths and sizes, units are a way to tell how strong your drink is, which can also help you to make comparisons.
How much is 100 units? ›The U-100 means there are 100 units in 1 milliliter.
How do you read a 100 unit insulin syringe? ›Reading a 100 unit Insulin Syringe
Each line measures in 2 increments until it reaches a total capacity of 100 units.
Quick Links. Each ml contains 100 IU insulin human (equivalent to 3.5 mg). Each cartridge contains 3 ml of solution for injection, equivalent to 300 IU insulin. One IU (International Unit) corresponds to 0.035 mg of anhydrous human insulin*.
How many units of insulin if sugar is 200? ›
| Blood sugar level | Supplemental insulin dose |
|---|---|
| Higher than 200 mg per dL | Add 2 units of insulin |
| 150 to 200 mg per dL | Add 1 unit of insulin |
| 100 to 149 mg per dl | No change |
| 70 to 100 mg per dL | Subtract 1 unit of insulin |
Theoretically, to reduce 400 mg/dL blood sugar to about 100 mg/dL, you would need at least 10 units of insulin. However, depending on your weight and other factors, a higher dose of insulin is almost always required.
How many mL is 20 units of insulin? ›| Micrograms (mcg) | cc or ml syringe | Insulin syringe |
|---|---|---|
| 30 micrograms | 0.10 milliliters | 10 units |
| 45 micrograms | 0.15 milliliters | 15 units |
| 60 micrograms | 0.20 milliliters | 20 units |
| 90 micrograms | 0.30 milliliters | 30 units |
while 10 units of U-100 is 0.1 ml, 10 units of U-10 would be 1 ml; 10 units of U-500 would be 0.02 ml.
What is the difference between 100 units per mL and 200 units per mL? ›IDeg 200 units/mL contains the same number of units of insulin in half the volume compared with IDeg 100 units/mL and, when administered in the new FlexTouch pen device, can deliver as much as 160 units of insulin in a single injection.
How do you measure one unit of insulin? ›The insulin-to-carb ratio means you will take 1 unit of insulin for a certain amount of carbohydrate. For example, if your insulin-to-carb ratio is 1 unit of insulin for every 10 grams of carbohydrate (written 1:10), you will take 1 unit of insulin for every 10 grams of carbohydrate you eat.
How much insulin do I need if my sugar is 500? ›Thus: 500 ÷ total daily dose = the number of grams of carbs covered by 1 unit of rapid-acting insulin. If your total daily dose was 50, this would give you the following calculation: 500 ÷ 50 = 10. This would mean that 10 grams of carbs would require 1 unit of insulin, giving you the ratio of 1:10.
Is Apidra the same as NovoLog? ›Summary. NovoLog (insulin aspart) is a fast-acting insulin that controls blood sugar around meal times for both type 1 and type 2 diabetes. Apidra (insulin glulisine) is a rapid-acting insulin that controls blood sugar for people with either type 1 diabetes or type 2 diabetes.
What strength is Apidra? ›APIDRA (insulin glulisine injection) is a sterile, aqueous, clear, and colorless solution for subcutaneous or intravenous use. Each milliliter of APIDRA contains 100 units (3.49 mg) insulin glulisine, 3.15 mg metacresol, 6 mg tromethamine, 5 mg sodium chloride, 0.01 mg polysorbate 20, and water for injection.
Are Apidra and Lantus the same? ›Lantus(R) SoloSTAR(R) and Apidra(R) SoloSTAR(R) are disposable prefilled insulin pens. Needles and the pens must not be shared. Lantus(R) SoloSTAR(R) pen is grey and Apidra(R) SoloSTAR(R) pen is blue. Each contains a different type of insulin (long-acting vs.
When should you take Apidra? ›
Apidra helps you manage your blood sugar at mealtime. You can take it within 15 minutes before or within 20 minutes after starting a meal.
Which insulin lasts the longest? ›Tresiba is sometimes called an ultra-long-acting insulin since its effects can last over 24 hours. In fact, it's the longest acting insulin available.
What is the benefit of Apidra? ›Prescription Apidra is a fast (rapid) acting insulin used for adults and children with diabetes mellitus to control high blood sugar.
How much is Apidra out of pocket? ›The cost for Apidra injectable solution (100 units/mL) is around $309 for a supply of 10 milliliters, depending on the pharmacy you visit.
What insulin is $35 a month? ›Lilly's Insulin is $35 a Month with Insulin Affordability | Eli Lilly and Company. That's the most people living with diabetes who rely on Lilly insulin should have to pay. Updates now make it even easier for people to access the life-saving medicine they need. Get your $35 savings card here.
What type of insulin is Apidra? ›Apidra is a short-acting insulin that is used in combination with intermediate- or long-acting insulins or insulin analogues (modified forms of insulin). It may also be used in combination with antidiabetes medicines taken by mouth.
What is insulin glargine 100u mL 10ml? ›USES: Insulin glargine is used along with a proper diet and exercise program to control high blood sugar. It is used in people with type 1 (insulin-dependent) or type 2 (non-insulin-dependent) diabetes. Insulin glargine is a man-made, long-acting type of insulin that is similar to human insulin.
What does Apidra insulin do? ›Apidra is indicated for the treatment of adult patients with diabetes mellitus. Diabetes Mellitus is a chronic disorder characterised by hyperglycemia resulting from defects in insulin secretion, insulin action, or both.
Is Lantus and Apidra the same? ›Lantus(R) SoloSTAR(R) and Apidra(R) SoloSTAR(R) are disposable prefilled insulin pens. Needles and the pens must not be shared. Lantus(R) SoloSTAR(R) pen is grey and Apidra(R) SoloSTAR(R) pen is blue. Each contains a different type of insulin (long-acting vs.
What is the generic name for Apidra insulin? ›nateglinide, insulin glulisine.
How much does apidra cost without insurance? ›
The cost for Apidra SoloStar injectable solution (100 units/mL) is around $587 for a supply of 15 milliliters, depending on the pharmacy you visit.
How much is Apidra insulin? ›| Quantity | Per unit | Price |
|---|---|---|
| 10 milliliters | $30.85 | $308.50 |
- Insulin aspart (Novorapid) – takes effect approximately 10-20 minutes after injection.
- Insulin aspart (Fiasp) – takes effect approximately 5 minutes after injection.
- Insulin lispro (Humalog) – takes effect approximately 15-30 minutes after injection.